Since conventional ophthalmic solutions are rapidly eliminated and cannot provide and maintain an adequate concentration of the drug in the cul-de-sac. To solve these problems, we developed a thermo sensitive in situ gelling and mucoadhesive ophthalmic drug delivery system containing moxifloxacin HCl based on poloxamer analogs (15 %w/v poloxamer 407/15 %w/v poloxamer 188) and PEO (X2) (0.3 or 0.5% w/v Polyox WSR 301). The combined formulation would easily converted to stiff gel at physiological conditions and exhibited sufficient mucoadhesion force and gel strength to provide ocular bioavailability of the drug for a long period of time. A 32 full factorial design was employed in formulating the IODDS (In situ Ophthalmic Drug Delivery System) with two polymers: PF68 (Pluronic F 68) (X1) and PEO (Polyox WSR 301) (X2) as independent variables. Formulations were prepared and analyzed for the dependent variables i.e., gelation temperature (GT), gel strength (GS) and bio-adhesion force (BF) etc. Drug permeation data was fitted to different kinetic models. PF 68 loading was found to be significant for gelation temperature, PEO loading showed positive effect on the bio-adhesion force and found helpful to control the release rate of drug. It was found significant effect of both the polymers on gel strength and bioadhesion force properties but PF 68 was important for gel formation at temperature range 33-36 �°C. The quadratic mathematical model developed could be used to predict and to have the formulations with desired gelation temperature, gel strength, bioadhesion force to obtained proper drug release properties.
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